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biopax3:comment |
Authored: de Bono, B, 2007-01-10 10:27:18,
Edited: Jupe, S, 2010-02-03,
Reviewed: Mohammadi, M, 2007-02-06 21:44:35,
The ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which in turn affects the activity or expression of pro-apoptotic factors, which contribute to protection from apoptosis. AKT activation also blocks the activity of GSK-3b which could lead to additional antiapoptotic signals.
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