Source:http://www.reactome.org/biopax/48887BiochemicalReaction1612
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Authored: Castagnoli, L, 2006-10-10 13:09:34,
Edited: Orlic-Milacic, Marija, 2011-08-25,
Reviewed: Heldin, CH, 2008-02-12 09:44:02,
The Src homology 2 (SH2) domain of the phosphatidylinositol 3-kinase (PIK3) regulatory subunit (PIK3R1, i.e. PI3Kp85) binds to GAB1 in a phosphorylation-independent manner. GAB1 serves as a docking protein which recruits a number of downstream signalling proteins. PIK3R1 can bind to either GAB1 or phosphorylated GAB1.
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Binding of PIK3 regulatory alpha subunit to GRB2:GAB1
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