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biopax3:comment |
Authored: Jupe, S, 2009-04-23 16:22:25,
Edited: Jupe, S, 2009-09-09,
Reviewed: Akkerman, JW, 2009-06-03,
The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated.
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