Source:http://www.reactome.org/biopax/48887BiochemicalReaction3492
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Authored: Jupe, S, 2009-05-22 13:10:56,
Edited: Jupe, S, 2009-09-09,
Reviewed: Akkerman, JW, 2009-06-03,
The activation of adenylyl (adenylate) cyclase (AC) results in the production of adenosine-3',5'-monophosphate i.e. cyclic AMP. Humans have 9 genes encoding membrane-associated AC and one encoding a soluble AC. Two of the classes of heterotrimeric G-proteins are named according to their effect on AC; Gs stimulates all membrane-bound ACs (the s in Gs denotes AC stimulatory); the Gi class inhibits some AC isoforms, particularly 5 and 6. Beta-gamma subunits of heterotrimeric G-proteins can also regulate AC. Ca2+/Calmodulin activates some AC isoforms (1, 8 and 3) but is inhibitory to others (5 and 6).
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Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
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4.6.1.1
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