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Authored: Jassal, B, 2009-02-13 11:37:11, Edited: Jassal, B, 2009-02-13 11:37:11, Reviewed: D'Eustachio, P, 2009-03-02 09:24:35, The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein.
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Liganded Gs-activating GPCR acts as a GEF for Gs
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