Source:http://www.reactome.org/biopax/48887BiochemicalReaction3493
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Authored: Jupe, S, 2009-04-23 15:40:54,
Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes.,
Edited: Jupe, S, 2009-09-09,
Reviewed: Akkerman, JW, 2009-06-03
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cAMP degradation by Phosphodiesterases
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