| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Gopinathrao, G, 2008-05-19 18:50:15,
Polyamines increase the production of antizyme (AZ). The carboxy-terminal half of antizyme interacts with ODC, generating an inactive AZ:ODC heterodimer complex. A carboxy-terminal domain of ODC is exposed only within the heterodimer, and is the target for subsequent degradation. A domain within the amino-terminal portion of antizyme provides a function needed for efficient degradation of ODC by the proteasome. <br>The proteasome cycle starts with the processing of AZ:ODC, sequestering ODC and then degrading it to peptides but releasing AZ. AZ participates in additional rounds of binding and degradation. Antizyme-mediated inhibition and destruction of ODC reduces synthesis of polyamines. Additionally, antizyme also inhibits polyamine transport into the cell. Antizyme production is reduced, completing the regulatory circuit (Coffino, 2001).<br>The following illustration is adapted from a minireview by Pegg, 2006; J. Biol. Chem., Vol. 281, Issue 21, 14529-14532.,
Reviewed: D'Eustachio, P, 2008-06-12 17:57:32
|
| biopax3:xref |
http://identifiers.org/pubmed/10623564,
http://identifiers.org/pubmed/11265248,
http://identifiers.org/pubmed/16205122,
http://identifiers.org/pubmed/16459331,
urn:biopax:RelationshipXref:GENE ONTOLOGY_GO:0006521,
urn:biopax:UnificationXref:REACTOME DATABASE ID_350562,
urn:biopax:UnificationXref:REACTOME_REACT_13565_1
|
| biopax3:dataSource | |
| biopax3:displayName |
Regulation of ornithine decarboxylase (ODC)
|
| biopax3:organism | |
| biopax3:pathwayComponent | |
| biopax3:pathwayOrder |