Source:http://www.reactome.org/biopax/48887BiochemicalReaction5077
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Antizyme is a non-competitive inhibitor of ODC that is synthesized in response to an increase in polyamine concentration. Tight binding of the antizyme to the ODC monomer forming a heterodimer prevents enzymatic activity. The region of antizyme interacting with ODC is contained in a section involving residues 106â??212 in the COOH-terminal half of the antizyme molecule. The induction of antizyme thus leads to a loss of active ODC protein (Pegg, 2006 and references cited in that review). <br>,
Authored: Gopinathrao, G, 2008-05-19 18:50:15,
Reviewed: D'Eustachio, P, 2008-06-12 17:57:32
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| biopax3:xref |
http://identifiers.org/pubmed/12359729,
http://identifiers.org/pubmed/12660156,
http://identifiers.org/pubmed/16459331,
http://identifiers.org/pubmed/7811704,
http://identifiers.org/pubmed/9132164,
urn:biopax:UnificationXref:REACTOME DATABASE ID_350567,
urn:biopax:UnificationXref:REACTOME_REACT_13759_1
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| biopax3:dataSource | |
| biopax3:displayName |
Antizyme OAZ binds to Ornithine decarboxylase
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