Source:http://www.reactome.org/biopax/48887BiochemicalReaction5079
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Antizyme inhibitor blocks the effects of antizyme on ODC. It has substantial similarity to ODC itself but has no ODC activity. It binds to antizyme more tightly than ODC displacing ODC from the antizyme-ODC complex. Recent studies have shown that antizyme inhibitor is able to disrupt the interaction between all forms of mammalian antizyme and ODC (Murakami et al., 1996, Nilsson et al., 2000, Mangold and Leberer, 2005).,
Authored: Gopinathrao, G, 2008-05-19 18:50:15,
Reviewed: D'Eustachio, P, 2008-06-12 17:57:32
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| biopax3:xref |
http://identifiers.org/pubmed/10698696,
http://identifiers.org/pubmed/15355308,
http://identifiers.org/pubmed/15491992,
http://identifiers.org/pubmed/17900240,
http://identifiers.org/pubmed/8631929,
http://identifiers.org/pubmed/9349715,
http://identifiers.org/pubmed/9426243,
urn:biopax:UnificationXref:REACTOME DATABASE ID_350600,
urn:biopax:UnificationXref:REACTOME_REACT_13578_1
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| biopax3:dataSource | |
| biopax3:displayName |
Antizyme inhibitor binds to OAZ and stablizes ODC complex
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