Linked Life Data

11095465

Source:http://linkedlifedata.com/resource/pubmed/id/11095465

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2000-11-29
pubmed:abstractText
Experimental rodent studies demonstrate that insulin-like growth factor II (IGF-II) promotes fetal growth, whereas the nonsignaling IGF-II receptor (IGF2R) is inhibitory; in humans their influence is as yet unclear. A soluble, circulating form of IGF2R inhibits IGF-II mediated DNA synthesis and may therefore restrain fetal growth. We measured cord blood levels of IGF-II, soluble IGF2R, insulin, IGF-I, IGF-binding protein-1 (IGFBP-1), and IGFBP-3 and examined their relationships to weight, length, head circumference, ponderal index, and placental weight at birth in 199 normal term singletons. IGF-II levels correlated with levels of IGF-I (r = 0.29; P < 0.0005), IGFBP-3 (r = 0.45; P < 0.0005), and soluble IGF2R (r = 0.20; P < 0.005). Insulin and IGF-I were positively related to all parameters of size at birth. IGF-II was weakly related to ponderal index (r = 0.18; P < 0.05) and placental weight (r = 0.18; P < 0.05), and the molar ratio of IGF-II to IGF2R was also related to birth weight (r = 0.15; P < 0.05). Correlations between the IGFs and size at birth were stronger in nonprimiparous pregnancies; in these, IGF-I (r = 0.52; P < 0.0005), IGFBP-3 (r = 0.41; P < 0.0005), and the IGF-II to IGF2R ratio (r = 0.40; P < 0.0005) were most closely related to placental weight, together accounting for 39% of its variance. We demonstrate for the first time relationships between circulating IGF-II and soluble IGF2R levels and size at birth, supporting their putative opposing roles in human fetal growth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4266-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11095465-Body Constitution, pubmed-meshheading:11095465-Cohort Studies, pubmed-meshheading:11095465-Female, pubmed-meshheading:11095465-Fetal Blood, pubmed-meshheading:11095465-Human Growth Hormone, pubmed-meshheading:11095465-Humans, pubmed-meshheading:11095465-Infant, Newborn, pubmed-meshheading:11095465-Insulin, pubmed-meshheading:11095465-Insulin-Like Growth Factor Binding Protein 1, pubmed-meshheading:11095465-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:11095465-Insulin-Like Growth Factor I, pubmed-meshheading:11095465-Insulin-Like Growth Factor II, pubmed-meshheading:11095465-Male, pubmed-meshheading:11095465-Placenta, pubmed-meshheading:11095465-Pregnancy, pubmed-meshheading:11095465-Receptor, IGF Type 2, pubmed-meshheading:11095465-Reference Values, pubmed-meshheading:11095465-Regression Analysis
pubmed:year
2000
pubmed:articleTitle
Size at birth and cord blood levels of insulin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-1 (IGFBP-1), IGFBP-3, and the soluble IGF-II/mannose-6-phosphate receptor in term human infants. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood.
pubmed:affiliation
Department of Paediatrics, University of Cambridge, Addenbrookes Hospital, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't