Source:http://linkedlifedata.com/resource/umls/id/C0021666
MSH: A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.,NCI: Insulin-like growth factors I and II, also known as somatomedin C and somatomedin A, respectively, are single chain polypeptides which share an amino acid sequence homology of about 47% with insulin and about 31% with relaxin and with them comprise the insulin family of polypeptide growth factors. Their functions include mediation of growth hormone action, stimulation of growth of cultured cells, stimulation of the action of insulin, and involvement in development and growth. They appear to be autocrine regulators of cell proliferation.