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biopax3:comment |
As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to the host. This module mainly focuses on the endogenous negative regulation of the RIG-I-like receptor (RLR) family proteins RIG-I and MDA5.,
Authored: Garapati, P V, 2010-08-02,
Edited: Garapati, P V, 2010-08-02,
Reviewed: Kawai, T, Akira, S, 2010-10-30
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