Source:http://www.reactome.org/biopax/48887BiochemicalReaction2708
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Authored: Garapati, P V, 2010-08-02,
CYLD is an ovarian tumor (OTU) domain-containing deubiquitinating enzyme (DUB) and has been identified as a negative regulator of RIG-I mediated antiviral signaling. CYLD associates with the CARD domain of RIG-I and removes K63-linked ubiquitin from the RIG-I CARDs that are conjugated by the E3 ubiquitin ligase, TRIM25 and RNF135.,
Edited: Garapati, P V, 2010-08-22,
Reviewed: Kawai, T, Akira, S, 2010-10-30
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CYLD mediated deubiquitination of RIG-I
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