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|---|---|
| rdf:type | |
| biopax3:comment |
Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30,
PECAM-1/CD31 is a member of the immunoglobulin superfamily (IgSF) and has been implicated to mediate the adhesion and trans-endothelial migration of T-lymphocytes into the vascular wall, T cell activation and angiogenesis. It has six Ig homology domains within its extracellularly and an ITIM motif within its cytoplasmic region. PECAM-1 mediates cellular interactions by both homophilic and heterophilic interactions. The cytoplasmic domain of PECAM-1 contains tyrosine residues which serves as docking sites for recruitment of cytosolic signaling molecules. Under conditions of platelet activation, PECAM-1 is phosphorylated by Src kinase members. The tyrosine residues 663 and 686 are required for recruitment of the SH2 domain containing PTPs.,
Reviewed: Trowsdale, J, 2008-02-26 12:02:59
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| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
PECAM1 interactions
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| biopax3:organism | |
| biopax3:pathwayComponent |
http://www.reactome.org/biopax/48887BiochemicalReaction1073,
http://www.reactome.org/biopax/48887BiochemicalReaction1074,
http://www.reactome.org/biopax/48887BiochemicalReaction1075,
http://www.reactome.org/biopax/48887BiochemicalReaction1076,
http://www.reactome.org/biopax/48887BiochemicalReaction1077,
http://www.reactome.org/biopax/48887BiochemicalReaction867,
http://www.reactome.org/biopax/48887BiochemicalReaction868
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| biopax3:pathwayOrder |
http://www.reactome.org/biopax/48887PathwayStep1326,
http://www.reactome.org/biopax/48887PathwayStep1323,
http://www.reactome.org/biopax/48887PathwayStep1091,
http://www.reactome.org/biopax/48887PathwayStep1324,
http://www.reactome.org/biopax/48887PathwayStep1090,
http://www.reactome.org/biopax/48887PathwayStep1325,
http://www.reactome.org/biopax/48887PathwayStep1327
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