Source:http://www.reactome.org/biopax/48887BiochemicalReaction1075
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Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30,
PECAM-1 is capable of transmitting information into the cell following its engagement and becomes tyrosine-phosphorylated during the platelet aggregation process. The Src family of tyrosine kinases (more specifically, Src, Lyn, and c-src) has been widely implicated in the phosphorylation of PECAM-1. Conserved tyrosine residues (Tyr663 and Tyr686) within the PECAM-1 cytoplasmic ITIM motif have been shown to become phosphorylated. Tyrosine phosphorylation of PECAM-1 prompts its association with intracellular signal transduction molecules.,
Reviewed: Trowsdale, J, 2008-02-26 12:02:59
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Phoshorylation of PECAM-1 by Fyn or Lyn or c-Src
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2.7.10
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