Source:http://www.reactome.org/biopax/48887BiochemicalReaction867
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Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30,
Reviewed: Trowsdale, J, 2008-02-26 12:02:59,
The phosphorylation of two tandem tyrosine residues (Y663 and Y686) within the cytoplasmic domain of PECAM-1 is required for the downstream signalling events observed following PECAM-1 ligation. Both SH2 domains of SHP-1 are required in tandem to bind PECAM-1.
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Interaction of PECAM-1 and SHP-1
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