| pubmed-article:9641677 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9641677 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9641677 | lifeskim:mentions | umls-concept:C0003323 | lld:lifeskim |
| pubmed-article:9641677 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:9641677 | lifeskim:mentions | umls-concept:C0019691 | lld:lifeskim |
| pubmed-article:9641677 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:9641677 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:9641677 | pubmed:issue | 6686 | lld:pubmed |
| pubmed-article:9641677 | pubmed:dateCreated | 1998-7-1 | lld:pubmed |
| pubmed-article:9641677 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9641677 | pubmed:abstractText | The entry of human immunodeficiency virus (HIV) into cells requires the sequential interaction of the viral exterior envelope glycoprotein, gp120, with the CD4 glycoprotein and a chemokine receptor on the cell surface. These interactions initiate a fusion of the viral and cellular membranes. Although gp120 can elicit virus-neutralizing antibodies, HIV eludes the immune system. We have solved the X-ray crystal structure at 2.5 A resolution of an HIV-1 gp120 core complexed with a two-domain fragment of human CD4 and an antigen-binding fragment of a neutralizing antibody that blocks chemokine-receptor binding. The structure reveals a cavity-laden CD4-gp120 interface, a conserved binding site for the chemokine receptor, evidence for a conformational change upon CD4 binding, the nature of a CD4-induced antibody epitope, and specific mechanisms for immune evasion. Our results provide a framework for understanding the complex biology of HIV entry into cells and should guide efforts to intervene. | lld:pubmed |
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| pubmed-article:9641677 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9641677 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9641677 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9641677 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9641677 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:9641677 | pubmed:author | pubmed-author:HendricksonW... | lld:pubmed |
| pubmed-article:9641677 | pubmed:author | pubmed-author:RobinsonJJ | lld:pubmed |
| pubmed-article:9641677 | pubmed:author | pubmed-author:SweetR WRW | lld:pubmed |
| pubmed-article:9641677 | pubmed:author | pubmed-author:WyattRR | lld:pubmed |
| pubmed-article:9641677 | pubmed:author | pubmed-author:SodroskiJJ | lld:pubmed |
| pubmed-article:9641677 | pubmed:author | pubmed-author:KwongP DPD | lld:pubmed |
| pubmed-article:9641677 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9641677 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:9641677 | pubmed:volume | 393 | lld:pubmed |
| pubmed-article:9641677 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9641677 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9641677 | pubmed:pagination | 648-59 | lld:pubmed |
| pubmed-article:9641677 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9641677 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9641677 | pubmed:articleTitle | Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. | lld:pubmed |
| pubmed-article:9641677 | pubmed:affiliation | Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA. | lld:pubmed |
| pubmed-article:9641677 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9641677 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9641677 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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