|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
1997-4-24
|
|
pubmed:abstractText |
Tumor necrosis factor alpha (TNF-alpha) plays a crucial role in the pathogenesis of the central nervous system infections. In an in vitro reconstructed blood-brain barrier model, a significant dysregulation of receptor mediated endocytosis of low density lipoproteins (LDL) and transferrin (Tf) is demonstrated at delayed phase of direct TNF-alpha activation. Concomitant with the increase in LDL uptake, we demonstrate a decrease of Tf-receptor mediated endocytosis. The potential role of TNF action in the differential or opposite routing of macromolecules is also characterized by a stimulation of their transcytosis. These findings may provide a new insight into the inflammatory effect of TNF-alpha on brain capillary endothelial cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0165-5728
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
74
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
173-84
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9119971-Animals,
pubmed-meshheading:9119971-Biological Transport,
pubmed-meshheading:9119971-Blood-Brain Barrier,
pubmed-meshheading:9119971-Capillaries,
pubmed-meshheading:9119971-Capillary Permeability,
pubmed-meshheading:9119971-Cattle,
pubmed-meshheading:9119971-Cells, Cultured,
pubmed-meshheading:9119971-Cerebrovascular Circulation,
pubmed-meshheading:9119971-Cytoskeleton,
pubmed-meshheading:9119971-Endocytosis,
pubmed-meshheading:9119971-Endothelium, Vascular,
pubmed-meshheading:9119971-Inulin,
pubmed-meshheading:9119971-Lipoproteins, LDL,
pubmed-meshheading:9119971-Macromolecular Substances,
pubmed-meshheading:9119971-Rats,
pubmed-meshheading:9119971-Receptors, Transferrin,
pubmed-meshheading:9119971-Sucrose,
pubmed-meshheading:9119971-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Effects of tumor necrosis factor on receptor-mediated endocytosis and barrier functions of bovine brain capillary endothelial cell monolayers.
|
|
pubmed:affiliation |
Inserm U325-Serlia, Institut Pasteur, Lille, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
