Receptor Mediated Endocytosis

Source:http://linkedlifedata.com/resource/umls/id/C0597361

GO: An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. [GOC:mah, ISBN:0716731363],CSP: pathway for taking up substances which first bind to specific cell surface receptors in coated pits and are then internalized by endocytosis; also internalizes obsolete cell surface receptors.,NCI: A process by which cells internalize molecules or viruses. Receptors on the plasma membrane of the target cell bind to specific cell surface receptorson the endocytic cells, inducing formation of coated pits and endocytic invagination of the plasma membrane.

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