|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003501,
umls-concept:C0003693,
umls-concept:C0041904,
umls-concept:C0086418,
umls-concept:C0181586,
umls-concept:C0225360,
umls-concept:C0439793,
umls-concept:C1261287,
umls-concept:C1280500,
umls-concept:C1704259,
umls-concept:C1705987
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2011-3-29
|
|
pubmed:abstractText |
The development of aortic valve stenosis is not only associated with calcification and extracellular matrix remodeling, but also with inflammation. The aim of this study was to determine the role of proinflammatory signaling through the leukotriene (LT) pathway in aortic stenosis.
|
|
pubmed:commentsCorrections |
|
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1524-4539
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
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pubmed:day |
29
|
|
pubmed:volume |
123
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1316-25
|
|
pubmed:dateRevised |
2011-9-15
|
|
pubmed:meshHeading |
pubmed-meshheading:21403093-Aged,
pubmed-meshheading:21403093-Aortic Valve,
pubmed-meshheading:21403093-Aortic Valve Stenosis,
pubmed-meshheading:21403093-Arachidonate 5-Lipoxygenase,
pubmed-meshheading:21403093-Cells, Cultured,
pubmed-meshheading:21403093-Echocardiography,
pubmed-meshheading:21403093-Female,
pubmed-meshheading:21403093-Fibroblasts,
pubmed-meshheading:21403093-Gene Expression Profiling,
pubmed-meshheading:21403093-Humans,
pubmed-meshheading:21403093-Immunohistochemistry,
pubmed-meshheading:21403093-Leukotriene C4,
pubmed-meshheading:21403093-Male,
pubmed-meshheading:21403093-Middle Aged,
pubmed-meshheading:21403093-Mitral Valve,
pubmed-meshheading:21403093-Myocarditis,
pubmed-meshheading:21403093-Receptors, Leukotriene,
pubmed-meshheading:21403093-Severity of Illness Index,
pubmed-meshheading:21403093-Signal Transduction,
pubmed-meshheading:21403093-Tricuspid Valve,
pubmed-meshheading:21403093-Up-Regulation
|
|
pubmed:year |
2011
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|
pubmed:articleTitle |
Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts.
|
|
pubmed:affiliation |
Center for Molecular Medicine, CMM L8:03, Karolinska University Hospital, Stockholm, Sweden. edit.nagy@karolinska.se
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
