Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-8-13
pubmed:abstractText
The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up-regulation of PDGF-A, PDGF receptors alpha and beta, and TGF-beta expression occurred in allografts, whereas PDGF-B and CTGF expression was similar in allo- and autografts. Imatinib modified the inflammatory responses and expression patterns of PDGF-A and PDGF receptors. This study further confirms PDGF and TGF-beta as mediators of OB and supports the concept of the importance of the pathways signaled through PDGF receptors in post-transplant OB.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Connective Tissue Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Piperazines, http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-sis, http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Platelet-Derived Growth..., http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Platelet-Derived Growth..., http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta, http://linkedlifedata.com/resource/pubmed/chemical/imatinib, http://linkedlifedata.com/resource/pubmed/chemical/platelet-derived growth factor A
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0190-2148
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-20
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17694440-Animals, pubmed-meshheading:17694440-Bronchi, pubmed-meshheading:17694440-Bronchiolitis Obliterans, pubmed-meshheading:17694440-CD4-Positive T-Lymphocytes, pubmed-meshheading:17694440-CD8-Positive T-Lymphocytes, pubmed-meshheading:17694440-Connective Tissue Growth Factor, pubmed-meshheading:17694440-Disease Models, Animal, pubmed-meshheading:17694440-Graft Rejection, pubmed-meshheading:17694440-Immediate-Early Proteins, pubmed-meshheading:17694440-Immunohistochemistry, pubmed-meshheading:17694440-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:17694440-Macrophages, pubmed-meshheading:17694440-Piperazines, pubmed-meshheading:17694440-Platelet-Derived Growth Factor, pubmed-meshheading:17694440-Protein Kinase Inhibitors, pubmed-meshheading:17694440-Proto-Oncogene Proteins c-sis, pubmed-meshheading:17694440-Pyrimidines, pubmed-meshheading:17694440-Receptor, Platelet-Derived Growth Factor alpha, pubmed-meshheading:17694440-Receptor, Platelet-Derived Growth Factor beta, pubmed-meshheading:17694440-Signal Transduction, pubmed-meshheading:17694440-Sus scrofa, pubmed-meshheading:17694440-Time Factors, pubmed-meshheading:17694440-Transforming Growth Factor beta, pubmed-meshheading:17694440-Transplantation, Autologous, pubmed-meshheading:17694440-Transplantation, Homologous
pubmed:year
2007
pubmed:articleTitle
Platelet-derived growth factor, transforming growth factor-beta, and connective tissue growth factor in a porcine bronchial model of obliterative bronchiolitis.
pubmed:affiliation
Department of Surgery, Helsinki University Hospital, Helsinki, Finland. Hanni.Alho@helsinki.fi
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't