Source:http://linkedlifedata.com/resource/pubmed/id/17475873
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0009392,
umls-concept:C0018183,
umls-concept:C0024432,
umls-concept:C0026336,
umls-concept:C0026809,
umls-concept:C0031154,
umls-concept:C0079459,
umls-concept:C0079460,
umls-concept:C0079784,
umls-concept:C0232920,
umls-concept:C0439677,
umls-concept:C0678108,
umls-concept:C1155266,
umls-concept:C1709078
|
| pubmed:issue |
10
|
| pubmed:dateCreated |
2007-5-3
|
| pubmed:abstractText |
To assess the combined role of G-CSF, GM-CSF, and M-CSF in myeloid cell production, mice deficient in all three myeloid CSFs were generated (G-/-GM-/-M-/- mice). G-/-GM-/-M-/- mice share characteristics found in mice lacking individual cytokines: they are toothless and osteopetrotic and furthermore acquire alveolar proteinosis that is more severe than that found in either GM-/- or G-/-GM-/- mice. G-/-GM-/-M-/- mice have a significantly reduced lifespan, which is prolonged by antibiotic administration, suggesting compromised ability to control bacterial infection. G-/-GM-/-M-/- mice have circulating neutrophils and monocytes, albeit at significantly reduced numbers compared with wild-type mice, but surprisingly, have more circulating monocytes than M-/- mice and more circulating neutrophils than G-/-GM-/- mice. Due to severe osteopetrosis, G-/-GM-/-M-/- mice show diminished numbers of myeloid cells, myeloid progenitors, and B lymphocytes in the bone marrow, but have significantly enhanced compensatory splenic hemopoiesis. Although G-/-GM-/-M-/- mice have a profound deficiency of myeloid cells in the resting peritoneal cavity, the animals mount a moderate cellular response in a model of sterile peritonitis. These data establish that in the absence of G-CSF, GM-CSF, and M-CSF, additional growth factor(s) can stimulate myelopoiesis and acute inflammatory responses.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Colony-Stimulating Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte Colony-Stimulating...,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Colony-Stimulating Factor
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
178
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6435-43
|
| pubmed:meshHeading |
pubmed-meshheading:17475873-Animals,
pubmed-meshheading:17475873-Cell Differentiation,
pubmed-meshheading:17475873-Colony-Stimulating Factors,
pubmed-meshheading:17475873-Disease Models, Animal,
pubmed-meshheading:17475873-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:17475873-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:17475873-Granulocytes,
pubmed-meshheading:17475873-Inflammation Mediators,
pubmed-meshheading:17475873-Leukopenia,
pubmed-meshheading:17475873-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:17475873-Macrophages, Peritoneal,
pubmed-meshheading:17475873-Mice,
pubmed-meshheading:17475873-Mice, Inbred C57BL,
pubmed-meshheading:17475873-Mice, Knockout,
pubmed-meshheading:17475873-Mice, Mutant Strains,
pubmed-meshheading:17475873-Myeloid Cells,
pubmed-meshheading:17475873-Myelopoiesis,
pubmed-meshheading:17475873-Peritonitis
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Mice lacking three myeloid colony-stimulating factors (G-CSF, GM-CSF, and M-CSF) still produce macrophages and granulocytes and mount an inflammatory response in a sterile model of peritonitis.
|
| pubmed:affiliation |
Signal Transduction Laboratory, Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, and Department of Medicine, University of Melbourne, Parkville, Australia. Margaret.Hibbs@ludwig.edu.au
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|