Macrophage Colony-Stimulating Factor

Source:http://linkedlifedata.com/resource/umls/id/C0079784

MSH: A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).,NCI: This protein is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. It may also be involved in development of the placenta. (from LocusLink),NCI: Synthesized by mesenchymal cells, Macrophage Colony-Stimulating Factor is a 70 kD disulfide-bonded homodimeric glycoprotein cytokine that binds to FMS (a specific high affinity receptor) and stimulates survival, proliferation, and differentiation of committed hematopoietic

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