Source:http://linkedlifedata.com/resource/pubmed/id/17382365
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2007-6-4
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| pubmed:abstractText |
The pathogenicity of feline infectious peritonitis virus (FIPV) is known to depend on macrophage tropism, and this macrophage infection is enhanced by mediation via anti-S antibody (antibody-dependent enhancement, ADE). In this study, we found that TNF-alpha production was increased with viral replication in macrophages inoculated with a mixture of FIPV and anti-S antibody, and demonstrated that this culture supernatant had feline PBMC apoptosis-inducing activity. We also demonstrated that the expression level of the FIPV virus receptor, feline aminopeptidase N (fAPN), was increased in macrophages of FIP cats. For upregulation of TNF-alpha and fAPN in macrophages, viral replication in macrophages is necessary, and their expressions were increased by ADE of FIPV infection. It was demonstrated that a heat-resistant fAPN-inducing factor was present in the culture supernatant of FIPV-infected macrophages, and this factor was TNF-alpha: fAPN expression was upregulated in recombinant feline TNF-alpha-treated macrophages, and FIPV infectivity was increased in these macrophages. These findings suggested that FIPV replication in macrophages increases TNF-alpha production in macrophages, and the produced TNF-alpha acts and upregulates fAPN expression, increasing FIPV sensitivity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD13,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0042-6822
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
20
|
| pubmed:volume |
364
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
64-72
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| pubmed:meshHeading |
pubmed-meshheading:17382365-Animals,
pubmed-meshheading:17382365-Antigens, CD13,
pubmed-meshheading:17382365-Apoptosis,
pubmed-meshheading:17382365-Base Sequence,
pubmed-meshheading:17382365-Cats,
pubmed-meshheading:17382365-Cells, Cultured,
pubmed-meshheading:17382365-Coronavirus, Feline,
pubmed-meshheading:17382365-Culture Media, Conditioned,
pubmed-meshheading:17382365-DNA Primers,
pubmed-meshheading:17382365-Feline Infectious Peritonitis,
pubmed-meshheading:17382365-Leukocytes, Mononuclear,
pubmed-meshheading:17382365-Macrophages,
pubmed-meshheading:17382365-RNA, Messenger,
pubmed-meshheading:17382365-RNA, Viral,
pubmed-meshheading:17382365-Receptors, Virus,
pubmed-meshheading:17382365-Recombinant Proteins,
pubmed-meshheading:17382365-Tumor Necrosis Factor-alpha,
pubmed-meshheading:17382365-Up-Regulation,
pubmed-meshheading:17382365-Virus Replication
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| pubmed:year |
2007
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| pubmed:articleTitle |
TNF-alpha, produced by feline infectious peritonitis virus (FIPV)-infected macrophages, upregulates expression of type II FIPV receptor feline aminopeptidase N in feline macrophages.
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| pubmed:affiliation |
Department of Veterinary Infectious Disease, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034-8628, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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