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pubmed-article:16804395pubmed:abstractTextThe proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) plays a key role in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). Recently, a new transcription factor termed LITAF (lipopolysaccharide-induced TNF-alpha factor) was shown to mediate TNF-alpha expression in human macrophages by direct binding to specific sequences in the promoter region of the TNF-alpha gene.lld:pubmed
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pubmed-article:16804395pubmed:articleTitleA new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC.lld:pubmed
pubmed-article:16804395pubmed:affiliationDepartment of Surgery, Boston University School of Medicine, Boston, Massachusetts 02118, USA.lld:pubmed
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