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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-6-28
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pubmed:abstractText |
The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) plays a key role in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). Recently, a new transcription factor termed LITAF (lipopolysaccharide-induced TNF-alpha factor) was shown to mediate TNF-alpha expression in human macrophages by direct binding to specific sequences in the promoter region of the TNF-alpha gene.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1078-0998
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
581-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16804395-Colitis, Ulcerative,
pubmed-meshheading:16804395-Crohn Disease,
pubmed-meshheading:16804395-Cytokines,
pubmed-meshheading:16804395-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16804395-Gene Expression Regulation,
pubmed-meshheading:16804395-Humans,
pubmed-meshheading:16804395-Immunohistochemistry,
pubmed-meshheading:16804395-Inflammation,
pubmed-meshheading:16804395-Intestines,
pubmed-meshheading:16804395-Lipopolysaccharides,
pubmed-meshheading:16804395-Macrophages,
pubmed-meshheading:16804395-Nuclear Proteins,
pubmed-meshheading:16804395-RNA,
pubmed-meshheading:16804395-Transcription Factors,
pubmed-meshheading:16804395-Tumor Necrosis Factor-alpha
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pubmed:year |
2006
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pubmed:articleTitle |
A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC.
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pubmed:affiliation |
Department of Surgery, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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