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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-3-7
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pubmed:abstractText |
To investigate i) whether the Dialyzable Leukocyte Extract (DLE) modulates the production of proinflammatory cytokines in leukocytes activated by the bacterial cell wall components lipopolysaccharide (LPS), lipoteichoic acid (LTA), and peptidoglycan (PGN); ii) the effect of DLE on LPS-stimulated endothelial cells; and iii) whether the regulatory effect of DLE on inflammatory mediators is related to the modulation of Toll-like receptors (TLRs), NF-kappaB and cAMP signaling pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidoglycan,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/TLR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TLR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Teichoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Transfer Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/lipoteichoic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1023-3830
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-81
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:15750714-Cells, Cultured,
pubmed-meshheading:15750714-Cyclic AMP,
pubmed-meshheading:15750714-Endothelial Cells,
pubmed-meshheading:15750714-Humans,
pubmed-meshheading:15750714-Inflammation Mediators,
pubmed-meshheading:15750714-Interleukin-6,
pubmed-meshheading:15750714-Interleukin-8,
pubmed-meshheading:15750714-Leukocytes,
pubmed-meshheading:15750714-Lipopolysaccharides,
pubmed-meshheading:15750714-Membrane Glycoproteins,
pubmed-meshheading:15750714-Monocytes,
pubmed-meshheading:15750714-NF-kappa B,
pubmed-meshheading:15750714-Peptidoglycan,
pubmed-meshheading:15750714-Receptors, Cell Surface,
pubmed-meshheading:15750714-Teichoic Acids,
pubmed-meshheading:15750714-Toll-Like Receptor 2,
pubmed-meshheading:15750714-Toll-Like Receptor 4,
pubmed-meshheading:15750714-Toll-Like Receptors,
pubmed-meshheading:15750714-Transfer Factor,
pubmed-meshheading:15750714-Tumor Necrosis Factor-alpha
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pubmed:year |
2005
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pubmed:articleTitle |
Dialyzable leukocyte extract differentially regulates the production of TNFalpha, IL-6, and IL-8 in bacterial component-activated leukocytes and endothelial cells.
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pubmed:affiliation |
Division of Physical Chemistry, Center for Genetic Engineering and Biotechnology (CIGB), P.O. Box 6162, Havana, 10600, Cuba. miriam.ojeda@cigb.edu.cu
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pubmed:publicationType |
Journal Article
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