|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0018792,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0074554,
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C0225360,
umls-concept:C1269955,
umls-concept:C1456820,
umls-concept:C1514485,
umls-concept:C2699153
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|
pubmed:issue |
3
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|
pubmed:dateCreated |
2004-11-11
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|
pubmed:abstractText |
Tumor necrosis factor alpha (TNFalpha) is implicated in myocardial remodeling, a process in which activated cardiac fibroblasts (myofibroblasts) secrete matrix-degrading metalloproteinases (MMPs) and undergo increased proliferation and invasion. Statins are cholesterol-lowering drugs that also have direct cellular effects, which may underlie their ability to reduce myocardial remodeling. This study investigated the effect of TNFalpha on human cardiac myofibroblast proliferation, invasion and MMP-9 secretion, and determined whether these properties were modulated by simvastatin.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0008-6363
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
64
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
507-15
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15537504-Cell Count,
pubmed-meshheading:15537504-Cell Movement,
pubmed-meshheading:15537504-Cell Proliferation,
pubmed-meshheading:15537504-Cells, Cultured,
pubmed-meshheading:15537504-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:15537504-Heart Atria,
pubmed-meshheading:15537504-Humans,
pubmed-meshheading:15537504-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:15537504-Matrix Metalloproteinase 9,
pubmed-meshheading:15537504-Myoblasts, Cardiac,
pubmed-meshheading:15537504-Protein Binding,
pubmed-meshheading:15537504-RNA, Messenger,
pubmed-meshheading:15537504-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:15537504-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15537504-Simvastatin,
pubmed-meshheading:15537504-Tumor Necrosis Factor-alpha
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|
pubmed:year |
2004
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|
pubmed:articleTitle |
Tumor necrosis factor alpha induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin.
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|
pubmed:affiliation |
Institute for Cardiovascular Research, Academic Unit for Cardiovascular Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
