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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0059438,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0389003,
umls-concept:C0392760,
umls-concept:C0600139,
umls-concept:C1518174,
umls-concept:C1565860,
umls-concept:C1704263,
umls-concept:C1705323,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
2004-12-7
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pubmed:abstractText |
Overexpression of cyclooxygenase (COX)-2 has been implicated in many pathologic conditions, including cancer. One practical inference of this finding is that sustained inhibition of COX-2 could serve as a promising target for prevention or therapy of cancer. Conventional nonsteroidal antiinflammatory drugs (NSAIDs) and recently developed COX-2-specific inhibitors have shown considerable promise in prevention of some forms of human cancer; however, its application is limited due to severe toxic side effects on normal cells. Therefore, there is a need to define novel, nontoxic dietary constituents with proven chemopreventive effects through other pathways that also possess COX-2 but not COX-1 inhibitory activity. Recent studies on green tea and its major polyphenolic constituent (-)epigallocatechin-3-gallate (EGCG) have established its remarkable cancer preventive and some cancer therapeutic effects. Here, we show that EGCG inhibits COX-2 without affecting COX-1 expression at both the mRNA and protein levels, in androgen-sensitive LNCaP and androgen-insensitive PC-3 human prostate carcinoma cells. Based on our study, it is tempting to suggest that a combination of EGCG with chemotherapeutic drugs could be an improved strategy for prevention and treatment of prostate cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Catechin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tea,
http://linkedlifedata.com/resource/pubmed/chemical/Urokinase-Type Plasminogen Activator,
http://linkedlifedata.com/resource/pubmed/chemical/epigallocatechin gallate
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0020-7136
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
660-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15455372-Antineoplastic Agents,
pubmed-meshheading:15455372-Apoptosis,
pubmed-meshheading:15455372-Arachidonic Acid,
pubmed-meshheading:15455372-Catechin,
pubmed-meshheading:15455372-Cell Division,
pubmed-meshheading:15455372-Cyclooxygenase 1,
pubmed-meshheading:15455372-Cyclooxygenase 2,
pubmed-meshheading:15455372-Dinoprostone,
pubmed-meshheading:15455372-Humans,
pubmed-meshheading:15455372-Isoenzymes,
pubmed-meshheading:15455372-Male,
pubmed-meshheading:15455372-Membrane Proteins,
pubmed-meshheading:15455372-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:15455372-Prostatic Neoplasms,
pubmed-meshheading:15455372-RNA, Messenger,
pubmed-meshheading:15455372-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15455372-Tea,
pubmed-meshheading:15455372-Tumor Cells, Cultured,
pubmed-meshheading:15455372-Urokinase-Type Plasminogen Activator
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pubmed:year |
2005
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pubmed:articleTitle |
Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells.
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pubmed:affiliation |
University of Wisconsin, Department of Dermatology, 1300 University Ave., Madison, WI 53706, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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