Source:http://linkedlifedata.com/resource/umls/id/C1565860
NCI: An enzyme that speeds up the formation of substances that cause inflammation and pain. It may also cause tumor cells to grow. Some tumors have high levels of COX-2 and blocking its activity may reduce tumor growth.,NCI: Encoded by cytokine/mitogen-induced human PGHS2 Gene (PGHS Family), homodimeric microsomal membrane 604-aa 69-kD (precursor) Prostaglandin-Endoperoxide Synthase 2, with 1 EGF-like domain and 86-89% identity to mammalian PTGS2 proteins, is involved in prostanoid-induced inflammation and mitogenesis. A target of NSAIDs, rate-limiting PGHS2 dioxygenase and peroxidase activity converts arachidonate to prostaglandins and thromboxanes. COX2 induction stimulates peripheral nociceptors. Deregulated expression may enhance carcinogenic potential; weak expression in pheochromocytomas favors benign diagnosis. (from LocusLink, Swiss-Prot, OMIM, and NCI),NCI: A rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins, COX-2 is expressed in cells involved in inflammatory processes an