Source:http://linkedlifedata.com/resource/umls/id/C0389003
NCI: Encoded by human PTGS1 Gene (PGHS Family), alternative constitutive homodimeric monotopic ER membrane Prostaglandin-Endoperoxide Synthase 1 isoforms contain an EGF-like domain and identical N/C-regions: long (599-aa, 69-kD precursor) and short (562-aa). Additional glycosylated gene products with altered (uncleaved) signal peptide, COX3 and PCOX1A (lacking COX activity), reside in cell membranes. Rate-limiting in prostaglandin and thromboxane synthesis, bifunctional PTGS1 appears involved in cell signaling, angiogenesis, and tissue homeostasis. PGH COX activity converts arachidonate to PGG2; PGH peroxidase converts PGG2 to PGH2. COX1 is inhibited by NSAIDs such as aspirin (irreversible ser529 acetylation). (from LocusLink, Swiss-Prot, OMIM, and NCI),NCI: COX-1 is known to be present in most tissues as the housekeeper enzyme, maintains normal gastric mucosa and influences kidney function, while COX-2 is inducible by inflammation. They share 60% homology. The expression of Cox-1 is induced by cytokines and