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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-9-16
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pubmed:abstractText |
Parathyroid hormone related protein (PTHrP) has been identified as the major hormone responsible for the syndrome of humoral hypercalcemia of malignancy (HHM). Recent studies have shown that a large number of prostate tumors demonstrate the presence of PTHrP despite the fact that prostate cancer is rarely associated with the HHM syndrome. Other studies have indicated that PTHrP behaves as an early response gene, which stimulates ornithine decarboxylase (ODC) enzyme activity, an enzyme, involved in the biosynthesis of polyamines. It is therefore possible that PTHrP regulates prostate tumor cell proliferation via ODC gene expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0301-1623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
417-22
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pubmed:dateRevised |
2006-6-29
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pubmed:meshHeading |
pubmed-meshheading:12230264-Adenocarcinoma,
pubmed-meshheading:12230264-Blotting, Northern,
pubmed-meshheading:12230264-DNA,
pubmed-meshheading:12230264-Dihydrotestosterone,
pubmed-meshheading:12230264-Gene Expression,
pubmed-meshheading:12230264-Humans,
pubmed-meshheading:12230264-Male,
pubmed-meshheading:12230264-Ornithine Decarboxylase,
pubmed-meshheading:12230264-Parathyroid Hormone-Related Protein,
pubmed-meshheading:12230264-Peptide Hormones,
pubmed-meshheading:12230264-Prostatic Neoplasms,
pubmed-meshheading:12230264-RNA, Messenger,
pubmed-meshheading:12230264-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Effect of parathyroid hormone related protein, and dihydrotestosterone on proliferation and ornithine decarboxylase mRNA in human prostate cancer cell lines.
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pubmed:affiliation |
Department of Medicine, VA West Side Medical Center and University of Illinois College of Medicine, Chicago, USA. akfarrok@UIC.edu
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pubmed:publicationType |
Journal Article
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