11543737

Source:http://linkedlifedata.com/resource/pubmed/id/11543737

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0086418, umls-concept:C0360105, umls-concept:C0596902, umls-concept:C0599682, umls-concept:C1099456, umls-concept:C1167622, umls-concept:C1979963, umls-concept:C2003903, umls-concept:C2911696
pubmed:issue	5
pubmed:dateCreated	2001-9-6
pubmed:abstractText	Single isomers of the selective serotonin reuptake inhibitors citalopram (escitalopram, S-citalopram) and fluoxetine (R-fluoxetine) are currently under development for the treatment of depression and other psychiatric disorders. Previous studies conducted in laboratory animals have revealed that the biological effects on serotonin reuptake for citalopram reside in the S enantiomer. In contrast, both enantiomers of fluoxetine contribute to its biological activity.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0213264
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Citalopram, http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport..., http://linkedlifedata.com/resource/pubmed/chemical/Fluoxetine, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine Plasma Membrane..., http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter, http://linkedlifedata.com/resource/pubmed/chemical/SLC6A2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/SLC6A4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane..., http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Uptake Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Symporters
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0006-3223
pubmed:author	pubmed-author:KnightD LDL, pubmed-author:NemeroffC BCB, pubmed-author:OwensM JMJ
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	50
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	345-50
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:11543737-Animals, pubmed-meshheading:11543737-Binding, Competitive, pubmed-meshheading:11543737-Brain, pubmed-meshheading:11543737-Carrier Proteins, pubmed-meshheading:11543737-Citalopram, pubmed-meshheading:11543737-Dopamine Plasma Membrane Transport Proteins, pubmed-meshheading:11543737-Dose-Response Relationship, Drug, pubmed-meshheading:11543737-Fluoxetine, pubmed-meshheading:11543737-Humans, pubmed-meshheading:11543737-Membrane Glycoproteins, pubmed-meshheading:11543737-Membrane Transport Proteins, pubmed-meshheading:11543737-Nerve Tissue Proteins, pubmed-meshheading:11543737-Norepinephrine Plasma Membrane Transport Proteins, pubmed-meshheading:11543737-Receptors, Neurotransmitter, pubmed-meshheading:11543737-Serotonin Plasma Membrane Transport Proteins, pubmed-meshheading:11543737-Serotonin Uptake Inhibitors, pubmed-meshheading:11543737-Stereoisomerism, pubmed-meshheading:11543737-Structure-Activity Relationship, pubmed-meshheading:11543737-Symporters
pubmed:year	2001
pubmed:articleTitle	Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine.
pubmed:affiliation	Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't