Source:http://linkedlifedata.com/resource/umls/id/C1099456
NCI: The active S-stereoisomer of the selective serotonin reuptake inhibitor (SSRI) citalopram with antidepressant, anti-obsessive-compulsive and antibulimic properties. Escitalopram inhibits the reuptake of the neurotransmitter serotonin (5-HT) at the serotonin reuptake pump of the neuronal membrane of the presynaptic cell, thereby increasing levels of 5-HT within the synaptic cleft and enhancing the actions of serotonin on 5HT1A autoreceptors. Unlike other SSRIs, escitalopram appears to not only bind to a primary high-affinity site on the serotonin transporter protein but also to a secondary lower-affinity allosteric site that is considered to stabilize and prolong drug binding.,NCI: A drug used to treat depression and certain anxiety disorders. It belongs to the family of drugs called selective serotonin reuptake inhibitors (SSRIs).,NCI: A drug used to treat depression and certain anxiety disorders. It belongs to the family of drugs called selective serotonin reuptake inhibitors (SSRIs).,MSH: S-enantiomer