Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2001-6-27
pubmed:abstractText
Thirty-three evaluable patients with Hodgkin's disease who failed radiotherapy were treated on this phase II study with bleomycin, lomustine, cyclophosphamide, vincristine, procarbazine and prednisone given every 28 days for a minimum of eight courses. Twenty-five patients (76%; 95% CI=55.6-87.1%) achieved a complete remission, the median duration of which cannot yet be determined, but the probability of remaining in continuous complete remission at 10 years is.64. The median survival from entry on this study for all evaluable patients is 10 years, and 12 patients were alive at the time of this analysis with a median follow-up for them of 15.5 years. Of the 22 patients who died, 11 died of progressive or recurrent Hodgkin's disease and 11 died of other causes including 7 second primary neoplasms and at least one myocardial infarction. Both are now well known late complications of Hodgkin's disease treatment.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1042-8194
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
357-63
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11426558-Adolescent, pubmed-meshheading:11426558-Adult, pubmed-meshheading:11426558-Aged, pubmed-meshheading:11426558-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:11426558-Bleomycin, pubmed-meshheading:11426558-Cause of Death, pubmed-meshheading:11426558-Cohort Studies, pubmed-meshheading:11426558-Cyclophosphamide, pubmed-meshheading:11426558-Female, pubmed-meshheading:11426558-Hodgkin Disease, pubmed-meshheading:11426558-Humans, pubmed-meshheading:11426558-Lomustine, pubmed-meshheading:11426558-Lymphatic Irradiation, pubmed-meshheading:11426558-Male, pubmed-meshheading:11426558-Middle Aged, pubmed-meshheading:11426558-Prednisone, pubmed-meshheading:11426558-Procarbazine, pubmed-meshheading:11426558-Recurrence, pubmed-meshheading:11426558-Survival Analysis, pubmed-meshheading:11426558-Treatment Outcome, pubmed-meshheading:11426558-Vincristine
pubmed:year
2001
pubmed:articleTitle
Bleomycin, lomustine, cyclophosphamide, vincristine, procarbazine and prednisone (BLEO-CCVPP) in patients with Hodgkin's disease who relapsed after radiotherapy alone: a long-term follow-up study of the Eastern Cooperative Oncology Group (E3481).
pubmed:affiliation
OLM Comprehensive Cancer Center, New York Medical College, Bronx 10466, USA. wiernik@jimmy.harvard.edu
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Clinical Trial, Phase II