Source:http://linkedlifedata.com/resource/umls/id/C0023972
MSH: An alkylating agent of value against both hematologic malignancies and solid tumors.,CSP: cytotoxic alkylating agent of the nitrosourea group used as an antineoplastic.,NCI: An anticancer drug that belongs to the family of drugs called alkylating agents.,PDQ: A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43065&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43065&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C617" NCI Thesaurus),NCI: A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby