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rdf:type |
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lifeskim:mentions |
umls-concept:C0007595,
umls-concept:C0012155,
umls-concept:C0030518,
umls-concept:C0031603,
umls-concept:C0040688,
umls-concept:C0086597,
umls-concept:C0249197,
umls-concept:C0288472,
umls-concept:C0851285,
umls-concept:C1420626,
umls-concept:C1527195
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pubmed:issue |
3
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pubmed:dateCreated |
2001-3-20
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pubmed:abstractText |
The parathyroid (PT) hyperplasia induced by renal failure can be further enhanced by high dietary phosphate (P) or completely abolished by P restriction. To identify potential mechanisms mediating these opposing effects of dietary P on PT growth, this study first focused on p21(WAF1) (p21) because high P reduces while low P enhances serum 1,25-dihydroxyvitamin D, whose potent antiproliferative properties result from the induction of p21. In addition to reducing p21, high P-induced PT growth could result from increased PT expression of the growth promoter transforming growth factor-alpha (TGF-alpha), known to be elevated in hyperplastic and adenomatous human PT glands.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
855-65
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11231340-Animals,
pubmed-meshheading:11231340-Cell Division,
pubmed-meshheading:11231340-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:11231340-Cyclins,
pubmed-meshheading:11231340-Diet,
pubmed-meshheading:11231340-Hyperparathyroidism, Secondary,
pubmed-meshheading:11231340-Hyperplasia,
pubmed-meshheading:11231340-Intestines,
pubmed-meshheading:11231340-Male,
pubmed-meshheading:11231340-Parathyroid Glands,
pubmed-meshheading:11231340-Phosphates,
pubmed-meshheading:11231340-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:11231340-RNA, Messenger,
pubmed-meshheading:11231340-Rats,
pubmed-meshheading:11231340-Rats, Sprague-Dawley,
pubmed-meshheading:11231340-Time Factors,
pubmed-meshheading:11231340-Transforming Growth Factor alpha,
pubmed-meshheading:11231340-Uremia
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pubmed:year |
2001
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pubmed:articleTitle |
p21(WAF1) and transforming growth factor-alpha mediate dietary phosphate regulation of parathyroid cell growth.
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pubmed:affiliation |
Renal Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. adusso@im.wustl.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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