Source:http://linkedlifedata.com/resource/pubmed/id/11200487
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-1-26
|
| pubmed:abstractText |
Insulin-like growth factor (IGF)-II is an important growth factor in development of the central nervous system. The purpose of this study was to evaluate expression of IGF-II and IGF receptor type 1 (IGFR1) in various pediatric brain tumors. Immunohistochemistry for IGF-II and IGFR1 was performed on 15 choroid plexus papillomas (CPPs) including 1 atypical CPP, 2 choroid plexus carcinomas (CPCs), 5 anaplastic ependymomas, 7 nonanaplastic ependymomas (simply referred to as "ependymoma"), 5 medulloblastomas, 1 cerebral neuroblastoma, and 1 atypical teratoid/rhabdoid tumor (ATRT) along with 10 non-neoplastic choroid plexus and 3 non-neoplastic ependymal linings. All non-neoplastic choroid plexus, CPPs, CPCs, anaplastic ependymomas, ATRT, 71% of ependymomas, and 67% of non-neoplastic ependymal linings showed cytoplasmic positivity for IGF-II, whereas all medulloblastomas and the cerebral neuroblastoma were negative for IGF-II. In addition to cytoplasmic positivity for IGFR1, membranous positivity was observed in 73% of CPPs, both CPCs, the ATRT, 22% of non-neoplastic choroid plexus, 80% of anaplastic ependymomas, and 29% of ependymomas, but not in any medulloblastoma, cerebral neuroblastoma, or non-neoplastic ependymal lining. IGF-II and IGFR1 may play roles in the pathogeneses of CPP, CPC, anaplastic ependymoma, ependymoma, and ATRT. Immunohistochemical testing for IGF-II and IGFR1 may be useful in differentiating ATRT, CPC, and anaplastic ependymoma from medulloblastoma and cerebral neuroblastoma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1093-5266
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
23-31
|
| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:11200487-Adolescent,
pubmed-meshheading:11200487-Adult,
pubmed-meshheading:11200487-Aged,
pubmed-meshheading:11200487-Carcinoma,
pubmed-meshheading:11200487-Cerebral Cortex,
pubmed-meshheading:11200487-Child,
pubmed-meshheading:11200487-Child, Preschool,
pubmed-meshheading:11200487-Choroid Plexus,
pubmed-meshheading:11200487-Choroid Plexus Neoplasms,
pubmed-meshheading:11200487-Ependymoma,
pubmed-meshheading:11200487-Humans,
pubmed-meshheading:11200487-Immunoenzyme Techniques,
pubmed-meshheading:11200487-Infant,
pubmed-meshheading:11200487-Infant, Newborn,
pubmed-meshheading:11200487-Insulin-Like Growth Factor II,
pubmed-meshheading:11200487-Medulloblastoma,
pubmed-meshheading:11200487-Papilloma,
pubmed-meshheading:11200487-Receptor, IGF Type 1,
pubmed-meshheading:11200487-Rhabdoid Tumor,
pubmed-meshheading:11200487-Telencephalon,
pubmed-meshheading:11200487-Teratoma
|
| pubmed:articleTitle |
Comparative immunohistochemical study of insulin-like growth factor II and insulin-like growth factor receptor type 1 in pediatric brain tumors.
|
| pubmed:affiliation |
Department of Pathology, University Hospitals of Cleveland and Case Western Reserve University, OH 44106, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|