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pubmed-article:9751673pubmed:abstractTextWe have previously shown that the application of ultrasound to thin-shelled microbubbles flowing through small microvessels (<7 microm in diameter) produces vessel wall ruptures in vivo. Because many intravascular drug- and gene-delivery vehicles are limited by the endothelial barrier, we hypothesized that this phenomenon could be used to deliver drug-bearing vehicles to tissue.lld:pubmed
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pubmed-article:9751673pubmed:articleTitleDelivery of colloidal particles and red blood cells to tissue through microvessel ruptures created by targeted microbubble destruction with ultrasound.lld:pubmed
pubmed-article:9751673pubmed:affiliationDepartment of Biomedical Engineering and the Cardiovascular Division, University of Virginia, Charlottesville, VA, USA. rprice@virginia.edulld:pubmed
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