| pubmed-article:9525607 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9525607 | lifeskim:mentions | umls-concept:C0035236 | lld:lifeskim |
| pubmed-article:9525607 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:9525607 | lifeskim:mentions | umls-concept:C0014457 | lld:lifeskim |
| pubmed-article:9525607 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:9525607 | lifeskim:mentions | umls-concept:C1819458 | lld:lifeskim |
| pubmed-article:9525607 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:9525607 | lifeskim:mentions | umls-concept:C0599537 | lld:lifeskim |
| pubmed-article:9525607 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9525607 | pubmed:dateCreated | 1998-4-17 | lld:pubmed |
| pubmed-article:9525607 | pubmed:abstractText | The respiratory syncytial virus (RSV) G glycoprotein promotes differentiation of type 2 CD4+ T lymphocytes and induces an eosinophilic response in lungs of RSV-infected mice. A unique feature of G is that a second initiation codon in the transmembrane region of the glycoprotein results in secretion of soluble protein from infected cells. Recombinant vaccinia viruses that express wild-type G (vvWT G), only secreted G (vvM48), or only membrane-anchored G (vvM48I) were used to define the influence of G priming on immunopathogenesis. Mice immunized with vvM48 had more severe illness following RSV challenge than did mice primed with vvWT G or vvM48I. Coadministration of purified G during priming with the construct expressing membrane-anchored G shifted immune responses following RSV challenge to a more Th2-like response. This was characterized by increased interleukin-5 in lung supernatants and an increase in G-specific immunoglobulin G1 antibodies. Eosinophils were present in the infiltrate of all mice primed with G-containing vectors but were greatest in mice primed with regimens including secreted G. These data suggest the form of G protein available for initial antigen processing and presentation is an important factor in promoting Th2-like immune responses, including the induction of lung eosinophilia. The ability of RSV to secrete G protein may therefore represent a viral strategy for immunomodulation and be a key determinant of disease pathogenesis. | lld:pubmed |
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| pubmed-article:9525607 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9525607 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9525607 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9525607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9525607 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9525607 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9525607 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:9525607 | pubmed:author | pubmed-author:JohnsonJ EJE | lld:pubmed |
| pubmed-article:9525607 | pubmed:author | pubmed-author:ParkerR ARA | lld:pubmed |
| pubmed-article:9525607 | pubmed:author | pubmed-author:GrahamB SBS | lld:pubmed |
| pubmed-article:9525607 | pubmed:author | pubmed-author:WertzG WGW | lld:pubmed |
