Linked Life Data

9525607

Source:http://linkedlifedata.com/resource/pubmed/id/9525607

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-4-17
pubmed:abstractText
The respiratory syncytial virus (RSV) G glycoprotein promotes differentiation of type 2 CD4+ T lymphocytes and induces an eosinophilic response in lungs of RSV-infected mice. A unique feature of G is that a second initiation codon in the transmembrane region of the glycoprotein results in secretion of soluble protein from infected cells. Recombinant vaccinia viruses that express wild-type G (vvWT G), only secreted G (vvM48), or only membrane-anchored G (vvM48I) were used to define the influence of G priming on immunopathogenesis. Mice immunized with vvM48 had more severe illness following RSV challenge than did mice primed with vvWT G or vvM48I. Coadministration of purified G during priming with the construct expressing membrane-anchored G shifted immune responses following RSV challenge to a more Th2-like response. This was characterized by increased interleukin-5 in lung supernatants and an increase in G-specific immunoglobulin G1 antibodies. Eosinophils were present in the infiltrate of all mice primed with G-containing vectors but were greatest in mice primed with regimens including secreted G. These data suggest the form of G protein available for initial antigen processing and presentation is an important factor in promoting Th2-like immune responses, including the induction of lung eosinophilia. The ability of RSV to secrete G protein may therefore represent a viral strategy for immunomodulation and be a key determinant of disease pathogenesis.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-1246465, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-1345785, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-1351433, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-1591217, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-1609551, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-2005433, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-2010624, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-2411951, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-2419587, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-2431051, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-2441388, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-2715331, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3183639, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3316707, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3373568, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3455762, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3497222, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3532115, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3553346, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3585282, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3655746, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3754878, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3755731, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3773052, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3858865, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-3939316, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-4305197, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-4305198, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-4715320, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-6201436, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-6707612, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-6834007, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-6886679, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7511681, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7523517, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7535865, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7595228, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7595230, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7636218, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7705400, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7729923, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7753199, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7753200, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7760935, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7760936, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7798649, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7836752, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-7962541, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8006306, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8091665, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8101549, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8207828, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8270885, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8345194, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8419171, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8470427, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8515055, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8557995, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8627759, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8662504, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8669890, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8683213, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8784786, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8829339, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8892899, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-8985399, http://linkedlifedata.com/resource/pubmed/commentcorrection/9525607-9062365
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-538X
pubmed:author
More...