Linked Life Data

9378999

Source:http://linkedlifedata.com/resource/pubmed/id/9378999

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1997-11-7
pubmed:abstractText
Acute lung allograft rejection is believed to be initiated by passenger leukocytes, such as alveolar macrophages (AM), in the donor organ, which release TNF-alpha, and present alloantigens to host lymphocytes, to up-regulated Th1 cellular and humoral immunity. However, the role of donor AM in local TNF-alpha synthesis, and their ability to induce local Th1 cellular and humoral immunity have not been evaluated. By depleting Brown Norway (BN, RT1n) rat lung allografts of AM before transplantation into Lewis rat (LEW, RT1(1)) recipients, the current study determined the role of donor AM in including the production of TNF-alpha, IFN-gamma (Th1 cytokine), IL-4 (Th2 cytokine), IgG subtypes, and rejection pathology in the allograft. The data show that compared with untreated BN allografts, pretransplant depletion of donor lung AM resulted in significantly less TNF-alpha, and IFN-gamma production in allograft bronchoalveolar lavage fluid with variable effects on local IL-4 production. Depletion of AM in the donor lung before transplantation affected the local production of several IgG subclasses. However, pretransplant depletion of donor AM had no effect on the development of the pathology of severe acute rejection. These data show that donor AM have a central role in the local synthesis of TNF-alpha and induce the production of IFN-gamma and IgG subtypes, locally, during acute lung allograft rejection. However, depletion of AM before transplantation does not prevent the development of severe acute rejection in BN rat lungs, transplanted into LEW recipients.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
159
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4084-93
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9378999-Animals, pubmed-meshheading:9378999-Bronchoalveolar Lavage Fluid, pubmed-meshheading:9378999-Cell Movement, pubmed-meshheading:9378999-Clodronic Acid, pubmed-meshheading:9378999-Cytokines, pubmed-meshheading:9378999-Graft Rejection, pubmed-meshheading:9378999-Immunoglobulin G, pubmed-meshheading:9378999-Immunosuppression, pubmed-meshheading:9378999-Inflammation, pubmed-meshheading:9378999-Intubation, Intratracheal, pubmed-meshheading:9378999-Leukopenia, pubmed-meshheading:9378999-Liposomes, pubmed-meshheading:9378999-Lung Transplantation, pubmed-meshheading:9378999-Macrophages, Alveolar, pubmed-meshheading:9378999-Male, pubmed-meshheading:9378999-Models, Biological, pubmed-meshheading:9378999-Rats, pubmed-meshheading:9378999-Rats, Inbred BN, pubmed-meshheading:9378999-Rats, Inbred Lew, pubmed-meshheading:9378999-Th1 Cells, pubmed-meshheading:9378999-Th2 Cells, pubmed-meshheading:9378999-Tissue Donors, pubmed-meshheading:9378999-Tumor Necrosis Factor-alpha
pubmed:year
1997
pubmed:articleTitle
Role of passenger leukocytes in allograft rejection: effect of depletion of donor alveolar macrophages on the local production of TNF-alpha, T helper 1/T helper 2 cytokines, IgG subclasses, and pathology in a rat model of lung transplantation.
pubmed:affiliation
Division of Cardiothoracic Surgery, Indiana University School of Medicine, Indianapolis 46202, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't