|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0016030,
umls-concept:C0017262,
umls-concept:C0021758,
umls-concept:C0034814,
umls-concept:C0035696,
umls-concept:C0040300,
umls-concept:C0127082,
umls-concept:C0162745,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1550315
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1997-3-18
|
|
pubmed:abstractText |
In the present study, we investigated the effect of interleukin-4 (IL-4) on metalloproteinase 1 (MMP-1/tissue collagenase) production in human rheumatoid synovial fibroblasts. Northern blot analysis revealed that addition of IL-4 with or without histamine stimulated the cells to increase the amount of proMMP-1 mRNA, and the IL-4 with histamine addition resulted in a 3.3-fold increase compared with histamine only. Furthermore, IL-4 itself stimulated the expression of histamine H1 receptor mRNA. These results suggest that IL-4 may play an important role in joint destruction in RA.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1039-9712
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
40
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1253-60
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8988338-Arthritis, Rheumatoid,
pubmed-meshheading:8988338-Blotting, Northern,
pubmed-meshheading:8988338-Blotting, Western,
pubmed-meshheading:8988338-Cells, Cultured,
pubmed-meshheading:8988338-Collagenases,
pubmed-meshheading:8988338-Enzyme Precursors,
pubmed-meshheading:8988338-Fibroblasts,
pubmed-meshheading:8988338-Humans,
pubmed-meshheading:8988338-Interleukin-4,
pubmed-meshheading:8988338-Matrix Metalloproteinase 1,
pubmed-meshheading:8988338-RNA, Messenger,
pubmed-meshheading:8988338-Receptors, Histamine H1,
pubmed-meshheading:8988338-Synovial Membrane
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Interleukin-4 stimulates rheumatoid synovial fibroblasts to express matrix metalloproteinase-1 (tissue collagenase) and histamine H1 receptor mRNA.
|
|
pubmed:affiliation |
Department of Pathology, School of Medicine, Kurume University, Japan.
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|
pubmed:publicationType |
Journal Article
|
