Linked Life Data

8869969

Source:http://linkedlifedata.com/resource/pubmed/id/8869969

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-1-21
pubmed:abstractText
Intercellular adhesion molecule-1 (ICAM-1) and class II major histocompatibility complex antigens (MHC II, HLA-DR), are two cell-surface ligands known to be critical to the initiation and propagation of immune-mediated inflammation. Their expression in tissue is induced by proinflammatory mediators, principally interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta. We examined human orbital fibroblasts and intact human orbital tissue exposed to these mediators for the presence of immunoreactive ICAM-1 and HLA-DR antigen. These ligands were detectable on stimulated fibroblasts and on fibroblasts and vascular endothelium in samples of orbital fat and muscle. ICAM-1 reactivity was diffuse and occurred in response to all three proinflammatory mediators. In contrast, HLA-DR reactivity was intense but limited to fewer numbers of cells. Our results, demonstrating the differential expression of these two ligands, may help further to elucidate the underlying pathogenetic mechanisms involved in the initiation and perpetuation of immune-mediated orbital inflammatory diseases.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0740-9303
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-62
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Differential expression of immunoreactive HLA-DR and ICAM-1 in human cultured orbital fibroblasts and orbital tissue.
pubmed:affiliation
Department of Ophthalmology, University of Michigon, Ann Arbor 48105, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't