Linked Life Data

8073012

Source:http://linkedlifedata.com/resource/pubmed/id/8073012

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-9-27
pubmed:abstractText
The role of cytokines in the pathogenesis of toxoplasmosis remains unknown to a large extent, especially in the case of reactivation that occurs in immunocompromised patients. To assess the importance of tumor necrosis factor alpha (TNF alpha), interleukin 1 alpha (IL1 alpha), and interleukin 6 (IL6), we studied the expression of these three cytokines by human astrocytoma cells after infection by three different strains of Toxoplasma gondii. The virulent RH strain, the intermediate 76K strain, and the cystogenic Prugniaud strain did not induce significantly different levels of expression of the cytokine messenger RNAs when the cytokines were studied at 1, 3, 6, and 24 h after parasitic infection. These results could indicate that infection by T. gondii strains of different virulence do not involve strong differences in TNF alpha, IL1 alpha, or IL6 expression by human astrocytoma cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0932-0113
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Tumor necrosis factor alpha, interleukin 1 alpha, and interleukin 6 mRNA expressed by human astrocytoma cells after infection by three different strains of Toxoplasma gondii.
pubmed:affiliation
Département de Parasitologie-Mycologie Médicale et Moléculaire, CNRS ERS 15, Faculté de Médecine, Université Joseph Fourier, Grenoble 1, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't