| pubmed-article:8055162 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8055162 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8055162 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8055162 | lifeskim:mentions | umls-concept:C0040688 | lld:lifeskim |
| pubmed-article:8055162 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8055162 | lifeskim:mentions | umls-concept:C1527195 | lld:lifeskim |
| pubmed-article:8055162 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:8055162 | lifeskim:mentions | umls-concept:C1523347 | lld:lifeskim |
| pubmed-article:8055162 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8055162 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8055162 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8055162 | pubmed:dateCreated | 1994-9-9 | lld:pubmed |
| pubmed-article:8055162 | pubmed:abstractText | We investigated the expression of transforming growth factor-alpha (TGF-alpha) and its receptor during human liver development and maturation, using immunohistochemistry. In the fetal liver, strong immunoreactivity for TGF-alpha and its receptor was noted in intrahepatic bile duct cells of various developmental stages; moderate immunoreactivity for TGF-alpha and mild immunoreactivity for TGF-alpha receptor were found in immature hepatocytes. In the postnatal liver, reactivity for TGF-alpha in hepatocytes decreased gradually and was negative or only weakly positive in the adult liver, while reactivity for TGF-alpha receptor in hepatocytes increased gradually and was strongly positive in the adult liver. In contrast, immunoreactivity of TGF-alpha and its receptor in intrahepatic bile duct cells persisted in the postnatal liver and was positive in the adult liver. These data suggest that the system of TGF-alpha and its receptor has an important role in the proliferation and differentiation of intrahepatic biliary cells and hepatocytes in the fetal liver. The decreasing expression of TGF-alpha in hepatocytes in the postnatal liver may indicate that proliferative activity of hepatocytes gradually decreases with liver maturation. The presence of TGF-alpha and its receptor in intrahepatic bile ducts in the postnatal liver suggests that the system of TGF-alpha and TGF-alpha receptor is operative postnatally. | lld:pubmed |
| pubmed-article:8055162 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8055162 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8055162 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8055162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8055162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8055162 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8055162 | pubmed:issn | 0945-6317 | lld:pubmed |
| pubmed-article:8055162 | pubmed:author | pubmed-author:TeradaTT | lld:pubmed |
| pubmed-article:8055162 | pubmed:author | pubmed-author:OhtaTT | lld:pubmed |
| pubmed-article:8055162 | pubmed:author | pubmed-author:NakanumaYY | lld:pubmed |
| pubmed-article:8055162 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8055162 | pubmed:volume | 424 | lld:pubmed |
| pubmed-article:8055162 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8055162 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8055162 | pubmed:pagination | 669-75 | lld:pubmed |
| pubmed-article:8055162 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8055162 | pubmed:meshHeading | pubmed-meshheading:8055162-... | lld:pubmed |
| pubmed-article:8055162 | pubmed:meshHeading | pubmed-meshheading:8055162-... | lld:pubmed |
| pubmed-article:8055162 | pubmed:meshHeading | pubmed-meshheading:8055162-... | lld:pubmed |
| pubmed-article:8055162 | pubmed:meshHeading | pubmed-meshheading:8055162-... | lld:pubmed |
| pubmed-article:8055162 | pubmed:meshHeading | pubmed-meshheading:8055162-... | lld:pubmed |
| pubmed-article:8055162 | pubmed:meshHeading | pubmed-meshheading:8055162-... | lld:pubmed |
| pubmed-article:8055162 | pubmed:meshHeading | pubmed-meshheading:8055162-... | lld:pubmed |
| pubmed-article:8055162 | pubmed:meshHeading | pubmed-meshheading:8055162-... | lld:pubmed |
| pubmed-article:8055162 | pubmed:meshHeading | pubmed-meshheading:8055162-... | lld:pubmed |
| pubmed-article:8055162 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8055162 | pubmed:articleTitle | Expression of transforming growth factor-alpha and its receptor during human liver development and maturation. | lld:pubmed |
| pubmed-article:8055162 | pubmed:affiliation | Second Department of Pathology, Kanazawa University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:8055162 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8055162 | lld:pubmed |
