Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1994-9-9
|
| pubmed:abstractText |
We investigated the expression of transforming growth factor-alpha (TGF-alpha) and its receptor during human liver development and maturation, using immunohistochemistry. In the fetal liver, strong immunoreactivity for TGF-alpha and its receptor was noted in intrahepatic bile duct cells of various developmental stages; moderate immunoreactivity for TGF-alpha and mild immunoreactivity for TGF-alpha receptor were found in immature hepatocytes. In the postnatal liver, reactivity for TGF-alpha in hepatocytes decreased gradually and was negative or only weakly positive in the adult liver, while reactivity for TGF-alpha receptor in hepatocytes increased gradually and was strongly positive in the adult liver. In contrast, immunoreactivity of TGF-alpha and its receptor in intrahepatic bile duct cells persisted in the postnatal liver and was positive in the adult liver. These data suggest that the system of TGF-alpha and its receptor has an important role in the proliferation and differentiation of intrahepatic biliary cells and hepatocytes in the fetal liver. The decreasing expression of TGF-alpha in hepatocytes in the postnatal liver may indicate that proliferative activity of hepatocytes gradually decreases with liver maturation. The presence of TGF-alpha and its receptor in intrahepatic bile ducts in the postnatal liver suggests that the system of TGF-alpha and TGF-alpha receptor is operative postnatally.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0945-6317
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
424
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
669-75
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:8055162-Adolescent,
pubmed-meshheading:8055162-Adult,
pubmed-meshheading:8055162-Child,
pubmed-meshheading:8055162-Child, Preschool,
pubmed-meshheading:8055162-Humans,
pubmed-meshheading:8055162-Infant,
pubmed-meshheading:8055162-Liver,
pubmed-meshheading:8055162-Receptor, Epidermal Growth Factor,
pubmed-meshheading:8055162-Transforming Growth Factor alpha
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Expression of transforming growth factor-alpha and its receptor during human liver development and maturation.
|
| pubmed:affiliation |
Second Department of Pathology, Kanazawa University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article
|