| pubmed-article:7935374 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7935374 | lifeskim:mentions | umls-concept:C0085262 | lld:lifeskim |
| pubmed-article:7935374 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:7935374 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:7935374 | lifeskim:mentions | umls-concept:C1434639 | lld:lifeskim |
| pubmed-article:7935374 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:7935374 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:7935374 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7935374 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:7935374 | pubmed:dateCreated | 1994-10-21 | lld:pubmed |
| pubmed-article:7935374 | pubmed:abstractText | Growth factor receptor tyrosine kinase regulation of the sequential phosphorylation reactions leading to mitogen-activated protein (MAP) kinase activation in PC12 cells has been investigated. In response to epidermal growth factor, nerve growth factor, and platelet-derived growth factor, B-Raf and Raf-1 are activated, phosphorylate recombinant kinase-inactive MEK-1, and activate wild-type MEK-1. MEK-1 is the dual-specificity protein kinase that selectively phosphorylates MAP kinase on tyrosine and threonine, resulting in MAP kinase activation. B-Raf and Raf-1 are growth factor-regulated Raf family members which regulate MEK-1 and MAP kinase activity in PC12 cells. Protein kinase A activation in response to elevated cyclic AMP (cAMP) levels inhibited B-Raf and Raf-1 stimulation in response to growth factors. Ras.GTP loading in response to epidermal growth factor, nerve growth factor, or platelet-derived growth factor was unaffected by protein kinase A activation. Even though elevated cAMP levels inhibited Raf activation, the growth factor activation of MEK-1 and MAP kinase was unaffected in PC12 cells. The results demonstrate that tyrosine kinase receptor activation of MEK-1 and MAP kinase in PC12 cells is regulated by B-Raf and Raf-1, whose activation is inhibited by protein kinase A, and MEK activators, whose activation is independent of cAMP regulation. | lld:pubmed |
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| pubmed-article:7935374 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7935374 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7935374 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7935374 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7935374 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7935374 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:7935374 | pubmed:author | pubmed-author:JohnsonG LGL | lld:pubmed |
| pubmed-article:7935374 | pubmed:author | pubmed-author:GardnerA MAM | lld:pubmed |
| pubmed-article:7935374 | pubmed:author | pubmed-author:VaillancourtR... | lld:pubmed |
| pubmed-article:7935374 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7935374 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:7935374 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7935374 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7935374 | pubmed:pagination | 6522-30 | lld:pubmed |
| pubmed-article:7935374 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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