Mitogen-Activated Protein Kinases

Source:http://linkedlifedata.com/resource/umls/id/C0752312

CSP: nonEC; family of protein kinases; mediate intracellular phosphorylation events that link receptor activation to the control of cell proliferation and differentiation.,MSH: A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).,NCI: Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases activated in response to a variety of extracellular stimuli and encoded by a multigene family. The MAPKs are part of complex protein kinase cascades. One of the several classes of MAPKs includes (among other ERKs) the extracellular signal-regulated kinases ERK1 (p44MAPK) and ERK2 (p42MAPK), activated by the RAF/MEK/ERK signaling pathway. ERK1/2 are widely involved in eukaryotic signal transduction. Upon activation

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