|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006141,
umls-concept:C0014939,
umls-concept:C0017262,
umls-concept:C0033308,
umls-concept:C0040688,
umls-concept:C0069515,
umls-concept:C0086418,
umls-concept:C0086661,
umls-concept:C0185117,
umls-concept:C0205183,
umls-concept:C0205282,
umls-concept:C0221198,
umls-concept:C0521115,
umls-concept:C1441616,
umls-concept:C1511790,
umls-concept:C1704824,
umls-concept:C2911684
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1994-11-10
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|
pubmed:abstractText |
The expression of transforming growth factor-alpha (TGF-alpha), epidermal growth factor receptor (EGF-R) and oncogenes c-erbB-2, c-H-ras, c-myc, as well as estrogen (ER) and progesterone (PR) receptors were studied immunohistochemically in the tissue of 21 benign and 58 malignant human breast lesions. Twenty nine (50%) of 58 carcinomas were positive for EGF-R and c-erbB-2 product, 55 (94.8%) for c-myc product, 9 (15.5%) for c-H-ras product and 17 (29%) for TGF-alpha. Eighteen of 58 (31%) carcinomas were estrogen receptor positive and 22 (38%) were positive for progesterone receptor. No correlation was found between expression of each investigated parameter and the clinical stage or degree of histological differentiation of the carcinomas. However, a significant positive correlation was observed between lymph node involvement and c-erbB-2 and EGF-R/c-erbB-2 positive tumors. A strong correlation was also observed between high levels of EGF-R and low levels of estrogen receptor. In 15 of 17 cases we found simultaneous expression of EGF-R and TGF-alpha. We also found interesting patterns in concomitant expression of the investigated parameters suggesting a possible cascade of events that occur in breast cancer cells.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
0258-851X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:geneSymbol |
c-H-ras,
c-erbB-2,
c-myc
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
N
|
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pubmed:pagination |
183-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7919121-Breast Diseases,
pubmed-meshheading:7919121-Breast Neoplasms,
pubmed-meshheading:7919121-Female,
pubmed-meshheading:7919121-Humans,
pubmed-meshheading:7919121-Immunohistochemistry,
pubmed-meshheading:7919121-Proto-Oncogene Proteins,
pubmed-meshheading:7919121-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:7919121-Receptor, Epidermal Growth Factor,
pubmed-meshheading:7919121-Receptor, erbB-2,
pubmed-meshheading:7919121-Receptors, Steroid,
pubmed-meshheading:7919121-Transforming Growth Factor alpha,
pubmed-meshheading:7919121-ras Proteins
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|
pubmed:articleTitle |
Immunohistochemical detection of TGF-alpha, EGF-R, c-erbB-2, c-H-ras, c-myc, estrogen and progesterone in benign and malignant human breast lesions: a concomitant expression.
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pubmed:affiliation |
Department of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.
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pubmed:publicationType |
Journal Article
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